![]() ![]() Dermal fillers specialize in repairing soft tissue volume loss and deep static wrinkles or folds, having advantages of simple operation, small trauma, short recovery time and obvious repair effect, etc. Skin aging, an inevitable physiological process, causes fundamental changes in the skin appearance and structure. These properties of size, morphology and degradation behavior would influence the foreign body reaction and collagen regeneration. PLLA ( = 3.80) microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine effect. ![]() The microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter time. In vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by microspheres. ![]() After these microspheres were fabricated dermal fillers according to the formula of Sculptra ®, they were injected subcutaneously into the back skin of rabbits. The in vitro degradation study showed that poly (L-lactic- co-glycolic acid) 75/25 microspheres degraded the fastest, whereas poly (L-lactic acid) (PLLA) microspheres with intrinsic viscosity of 6.89 ( = 6.89) with the highest molecular weight showed the slowest degradation rate. Polymer microspheres with 20–100 μm were prepared. Herein, eight biodegradable polymers with different molecular weights, chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine applications. The impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal fillers. Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical trials. ![]()
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